rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of β3-adrenergic receptor rs4994 polymorphisms with the risk of type 2 diabetes: A systematic review and meta-analysis.
|
28521197 |
2017 |
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
UCP1 -3826A/G and ADRB3 Trp64Arg polymorphisms may have a combined effect in the modulation of overweight/obesity and HDL-C levels in type 2 diabetes mellitus (T2DM) Caucasian-Brazilian patients.
|
24138564 |
2014 |
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study was undertaken to analyse a single nucleotide polymorphism Trp64Arg (C↔T) in the ADRB3 gene and elucidate its effects on type 2 diabetes and its associated risk factors.
|
23968135 |
2013 |
rs4994
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|
|
0.100 |
GeneticVariation |
BEFREE |
The β3-adrenoceptor (ADRB3) gene Trp64Arg polymorphism has been shown to be associated with obesity as well as type 2 diabetes and cardiovascular disease.
|
22609474 |
2012 |
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Under an additive genetic model, the C allele of ADRB3-rs4994, the C allele of ENPP1-rs1044498, and the A allele of PPARGC1A-rs8192678 increase the risk of type 2 diabetes in the Chinese Han population.
|
22391941 |
2012 |
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was an association between Trp64Arg и Arg64Arg genotypes and higher BMI, WC and obesity frequency (p < 0.00009), AO (p < 0.01), type 2 diabetes mellitus (DM) (p < 0.005) and lower high density cholesterol (HDL-C) level (p < 0.03).
|
21992420 |
2011 |
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Independent predictive roles of eotaxin Ala23Thr, paraoxonase 2 Ser311Cys and beta-adrenergic receptor Trp64Arg polymorphisms on cardiac disease in Type 2 Diabetes--an 8-year prospective cohort analysis of 1297 patients.
|
20536507 |
2010 |
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In contrast, the non-synonymous ADRB3 rs4994 polymorphism is associated with T2D and MS.
|
20503258 |
2010 |
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Some studies indicate that the Trp64Arg polymorphism in the gene encoding the beta(3)-adrenergic receptor (ADRB3) is associated with obesity, insulin resistance and earlier onset of type 2 diabetes mellitus.
|
18335327 |
2008 |
rs4994
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|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, the association of Trp64Arg with type 2 diabetes was examined in a meta-analysis.
|
18249022 |
2008 |
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Some studies indicate that the Trp64Arg polymorphism in the gene encoding the beta3-adrenergic receptor (ADRB3) is associated with obesity, insulin resistance and earlier onset of type 2 diabetes mellitus.
|
17852419 |
2007 |
rs4994
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|
|
0.100 |
GeneticVariation |
BEFREE |
Effect of the combination of the variants -75G/A APOA1 and Trp64Arg ADRB3 on the risk of type 2 diabetes (DM2).
|
17727676 |
2008 |
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We studied possible relations between GDM and both insulin receptor substrate 1 (IRS-1) (Gly972Arg) and beta3-adrenergic receptor (ADRB3 Trp64Arg, beta3-AR) gene mutations, considered potential modifying factors in the etiology of type 2 diabetes mellitus.
|
17046546 |
2006 |
rs4994
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|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, heterozygosity for the Trp64Arg variant is unlikely to increase the risk of obesity, insulin resistance or type 2 diabetes.
|
16634992 |
2006 |
rs4994
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|
|
0.100 |
GeneticVariation |
BEFREE |
The Trp64Arg polymorphism in the beta3AR gene has been reported to be associated with insulin resistance, obesity and type 2 diabetes; little is known about its possible association with cancer.
|
15743038 |
2004 |
rs4994
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|
|
0.100 |
GeneticVariation |
BEFREE |
To determine whether this SNP affects insulin resistance syndrome associated with type 2 diabetes, we examined its effects on susceptibility to obesity, hyperlipidemia and hypertension in type 2 diabetic subjects and on susceptibility to type 2 diabetes by interaction with other frequent genes involved in lipid metabolism, namely, beta3-adrenergic receptor (b3AR) Trp64Arg, phosphodiesterase 3B (PDE3B) c.1389G>A or lysosomal acid lipase (LAL) Thr-6Pro.
|
12965109 |
2003 |
rs4994
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|
|
0.100 |
GeneticVariation |
BEFREE |
The beta(3)-adrenergic receptor gene (BAR-3) allelic variant (Trp64Arg and Arg64Arg) is correlated with obesity or non-insulin-dependent diabetes mellitus.
|
12943691 |
2003 |
rs4994
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|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, no major difference was associated with the beta3AR Trp64Arg or FABP2 Ala54Thr polymorphism in terms of type 2 diabetes or hyperlipidemia in young to older Japanese men.
|
11699048 |
2001 |
rs4994
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|
|
0.100 |
GeneticVariation |
BEFREE |
Genotype Arg/Arg, but not Trp/Arg, of the Trp64Arg polymorphism of the beta(3)-adrenergic receptor is associated with type 2 diabetes and obesity in a large Japanese sample.
|
11522702 |
2001 |
rs4994
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|
|
0.100 |
GeneticVariation |
BEFREE |
Common variants in the beta2-(Gln27Glu) and beta3-(Trp64Arg)--adrenoceptor genes are associated with elevated serum NEFA concentrations and type II diabetes.
|
11380082 |
2001 |
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results suggest that the Trp64Arg mutation is not a major determinant of metabolic disorders (type 2 diabetes, obesity) and chronic complications of type 2 diabetes in a Dutch population.
|
11213599 |
2001 |
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Trp64Arg polymorphism of the beta3-adrenergic receptor gene is associated with hypertension in men with type 2 diabetes mellitus.
|
10981554 |
2000 |
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Trp64Arg beta3AR variant is associated in some, but not all, studies with an earlier onset of Type 2 diabetes mellitus and features of the insulin resistance syndrome.
|
10441039 |
1999 |
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Trp64Arg mutation is not a major determinant of Type 2 diabetes and its microangiopathic complications.
|
10197086 |
1998 |
rs4994
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Heterozygosity for the Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is not accompanied by obesity, impaired glucose tolerance and type 2 diabetes mellitus in the general elderly Dutch population, and is also not associated with changes in circulating leptin levels.
|
9828912 |
1998 |